The Tibetan Mastiff is the most expensive dog breed, with high grooming, healthcare, and feeding costs. Breed puppies cost $3,000 and live 10-12 years. These majestic, fluffy dogs need frequent grooming at $70 each. Their size protects them, but it also causes hip dysplasia, seizures, autoimmune diseases, and inherited demyelinating neuropathy. Veterinary visits and surgeries for these issues can cost hundreds to thousands of dollars.